TY - JOUR ID - 29348 TI - Survival of Patients with Ewing’s Sarcoma in Yazd-Iran JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 12 SP - 4861 EP - 4864 KW - Ewing’s sarcoma KW - Radiation therapy KW - Chemotherapy KW - survival DO - N2 - Background: The Ewing’s sarcoma family is a group of small round cell tumors which accounts for 10-15% of all primary bone neoplasms. The aim of this study was to evaluate the survival of Ewing’s sarcoma patients in our province and to determine of influencing factors. Materials and Methods: All patients with documented Ewing’s sarcoma/ primitive neuroectodermal tumor(PNET) family pathology were enrolled in this study during a period of eight years. For all of them local and systemic therapy were carried out. Overall and event free survivaland prognostic factors were evaluated. Results: Thirty two patients were enrolled in the study. The median age was 17.5 years. Twenty (65.2%) were male and 9 (28.1%) were aged 14 years or less. Mean disease free survival was 26.8 (95%CI; 13.8-39.9) months and five year disease free survival was 26%. Mean overall survival was 38.7 months (95%CI; 25.9-50.6) and median overall survival was 24 months. Five year overall survival was 25%. From the variables evaluated , only presence of metastatic disease at presentation (p value=0. 028) and completeresponse (p value =0. 006) had significant relations to overall survival. Conclusions: Survival of Ewing’s sarcoma in our province is disappointing. It seems to be mostly due to less effective treatment. Administration of adequatechemotherapy dosage, resection of tumor with negative margins and precise assessment of irradiation volume may prove helpful. UR - https://journal.waocp.org/article_29348.html L1 - https://journal.waocp.org/article_29348_d2bede57c6bb01bdb4e32111a2e6c5f2.pdf ER -