TY - JOUR ID - 29518 TI - Development and Clinical Evaluation of Dendritic Cell Vaccines or HPV Related Cervical Cancer - a Feasibility Study JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 14 SP - 5909 EP - 5916 KW - Dendritic Cells KW - Immunotherapy KW - cancer vaccines KW - cervical cancer KW - HPV DO - N2 - Human papillomavirus infection (HPV) and HPV related immune perturbation play important roles in thedevelopment of cervical cancer. Since mature dendritic cells (DCs) are potent antigen-presenting cells (APC),they could be primed by HPV antigens against cervical cancers. In this study we were able to generate, maintainand characterize, both phenotypically and functionally, patient specific dendritic cells in vitro. A randomizedPhase I trial with three arms - saline control (arm I), unprimed mature DC (arm II) and autologous tumor lysateprimed mature DC (arm III) and fourteen patients was conducted. According to WHO criteria, grade 0 or gradeone toxicity was observed in three patients. One patient who received tumor lysate primed dendritic cells andlater cis-platin chemotherapy showed a complete clinical response of her large metastatic disease and remaineddisease free for more than 72 months. Our findings indicate that DC vaccines hold promise as adjuvant sforcervical cancer treatment and further studies to improve their efficacy need to be conducted. UR - https://journal.waocp.org/article_29518.html L1 - https://journal.waocp.org/article_29518_37f3bd4e2a4ef805b59f5dd29b0c3023.pdf ER -