TY - JOUR ID - 29630 TI - Recently Emerging Signaling Landscape of Ataxia-Telangiectasia Mutated (ATM) Kinase JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 16 SP - 6485 EP - 6488 KW - Ataxia-telangiectasia mutated kinase KW - signalling landscape KW - Cancer therapy DO - N2 - Research over the years has progressively and sequentially provided near complete resolution of regulators of the DNA repair pathways which are so important for cancer prevention. Ataxia-telangiectasia mutated kinase (ATM), a high-molecular-weight PI3K-family kinase has emerged as a master regulator of DNA damage signaling and extensive cross-talk between ATM and downstream proteins forms an interlaced signaling network. There is rapidly growing scientific evidence emphasizing newly emerging paradigms in ATM biology. In this review,we provide latest information regarding how oxidative stress induced activation of ATM can be utilized as a therapeutic target in different cancer cell lines and in xenografted mice. Moreover, crosstalk between autophagy and ATM is also discussed with focus on how autophagy inhibition induces apoptosis in cancer cells. UR - https://journal.waocp.org/article_29630.html L1 - https://journal.waocp.org/article_29630_00073f4045870008d88c7087207b1ee2.pdf ER -