TY - JOUR ID - 29715 TI - Role of MicroRNAs in the Warburg Effect and Mitochondrial Metabolism in Cancer JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 17 SP - 7015 EP - 7019 KW - cancer KW - MicroRNAs KW - Warburg effect KW - mitochondria KW - Metabolism DO - N2 - Metabolism lies at the heart of cell biology. The metabolism of cancer cells is significantly different from that of their normal counterparts during tumorigenesis and progression. Elevated glucose metabolism is one of the hallmarks of cancer cells, even under aerobic conditions. The Warburg effect not only allows cancer cells to meet their high energy demands and supply biological materials for anabolic processes including nucleotide and lipid synthesis, but it also minimizes reactive oxygen species production in mitochondria, thereby providing a growth advantage for tumors. Indeed, the mitochondria also play a more essential role in tumor development. As information about the numorous microRNAs has emerged, the importance of metabolic phenotypes mediated by microRNAs in cancer is being increasingly emphasized. However, the consequences of dysregulation of Warburg effect and mitochondrial metabolism modulated by microRNAs in tumor initiation and progression are still largely unclear. UR - https://journal.waocp.org/article_29715.html L1 - https://journal.waocp.org/article_29715_a2f5df6c40667ccbec0ffbf09e6d95f1.pdf ER -