TY - JOUR ID - 29814 TI - Screening of Precancerous Gastric Lesions by Serum Pepsinogen, Gastrin-17, Anti-Helicobacter Pylori and Anti-Caga Antibodies in Dyspeptic Patients over 50 years Old in Guilan Province, North of Iran JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 18 SP - 7635 EP - 7638 KW - pepsinogen I KW - gastrin-17 KW - Helicobacter pylori antibodies KW - precancerous gastric lesion DO - N2 - Background: The aim of this study was to investigate the value of serum gastric markers to differentiatebetween patients with precancerous lesions and nonatrophic chronic gastritis. Materials and Methods: Serumsamples of 128 patients with dyspepsia who were candidates for endoscopic examination were tested forpepsinogen (PG I and PG II), PG I/II ratio, gastrin 17(G-17), anti-Helicobacter pylori (anti-H pylori ) and anti-CagA antibodies. Two sample t-tests, chi-square tests and Pearson’s correlation analyses were used for analysisusing SPSS (version 20). Results: PGI, PG I/II ratio values were decreased significantly in the precancerouslesion group (0.05, 0.001 respectively). The frequency of H pylori infection was significantly (p=0.03) differentbetween the two groups ofthe study. Conclusions: We suggest PGI and the PG I/II ratio as valuable markersfor screening of premalignant gastric lesions. UR - https://journal.waocp.org/article_29814.html L1 - https://journal.waocp.org/article_29814_a9d2f56557ea13e8e5e1d87f88a6205b.pdf ER -