TY - JOUR ID - 29885 TI - Gastrointestinal Adverse Effects in Advanced Colorectal Carcinoma Patients Treated with Different Schedules of FOLFOX JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 19 SP - 8089 EP - 8093 KW - FOLFOX KW - Colorectal carcinoma KW - stomatitis KW - Diarrhea KW - Nausea and Vomiting DO - N2 - Background: To assess the frequency and severity of gastrointestinal adverse effects in advanced colorectalcarcinoma patients treated with four different schedules of FOLFOX. Materials and Methods: Patients(median age 61 years) who underwent surgery were included in the study. All had measureable disease at CTscan, ultrasonography or clinical examination. Toxicity was graded on a scale of 1-5 according to the generalgrade definition of CTC v2.0. The severity of adverse effects (Grade 3 and 4) assessed in each treatment armwas compared. Results: Differences between the incidence rates of 3 and 4 toxicity and all grades of toxicityfor all parameters in GI toxicity were very highly significant (p<0.001). Severe gastrointestinal symptoms oftoxicity were noted with FOLFOX7 (oxaliplatin 130 mg/m2). Grade 3 diarrhea was reported in 25% patientsand grade 4 diarrhea in 4% in the FOLFOX7 treatment arm. Grade 2 vomiting was very frequently reported inthe FOLFOX4 treatment arm (oxaliplatin 85mg/m2). Grade 2 stomatitis was reported in 42% patients treatedwith mFOLFOX6 (oxaliplatin 100mg/m2). Differences in the incidence rate of nausea, diarrhea and stomatitisamong all treatment arms of FOLFOX were significant (p<0.05) . Conclusions: Severe diarrhea is associatedwith FOLFOX7 treatment. No grade 3 or 4 GI toxicity was reported in patients of the mFOLFOX6 arm. UR - https://journal.waocp.org/article_29885.html L1 - https://journal.waocp.org/article_29885_001f29cbee36d38dc212de9d88780518.pdf ER -