TY - JOUR ID - 29949 TI - Leucogen Tablets at 60 mg Three Times per Day are Safe and Effective to Control Febrile Neutropenia JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 19 SP - 8495 EP - 8497 KW - Leucogen tablets KW - cancer patients KW - Chemotherapy KW - febrile neutropenia DO - N2 - Purpose: To investigate whether it is safe to use leucogen tablets 60 mg three times per day (180 mg for a day)and whether this regimen could reduce the incidence of febrile neutropenia caused by chemotherapy. Methods:This prospectively designed study focused on the safety and effectiveness of leucogen tablets 60mg three timesper day for a group of cancer patients during chemotherapy for mainly lung or gastric cancers. The tabletswere administered from 5 days before until the termination of chemotherapy. Neutropenia and other healthcareencounters were defined as events and occurrence was estimated for comparison. Results: We identified 39patients receiving leucogen tablets 60mg three times per day, including 11 with gastric, 12 with lung and 16 withother sites of cancer. The mean age was 65 (29-75) years and there were 27 male and 12 female patients. Themean duration of leucogen tablets intake was 59 days. Eighteen patients were treated with taxane-based, 4 withirinotecan-based and 17 with other chemotherapy. The incidence of febrile neutropenia was 0%. Twelve patientswere found severe neutropenia (grade III/IV), and the duration of severe neutropenia (grade III/IV) was 5 days.Treatment-emergent adverse events were attributable to complications of myelosuppressive chemotherapy orthe primary disease (i.e., alopecia, nausea, asthenia, neutropenia, and severe hepatic renal dysfunction). Nochemotherapy was delayed and no treatment related death was observed. Conclusions: This study suggestedthat leucogen tablets 60mg three times per day (180mg for a day) are safe and could be effective for preventingfebrile neutropenia in patients with chemotherapy. UR - https://journal.waocp.org/article_29949.html L1 - https://journal.waocp.org/article_29949_195c55aaa5da7c0607291a8390424b52.pdf ER -