TY - JOUR ID - 30004 TI - Epidemiology of Hepatitis C Virus Genotypes in Northeastern Thai Blood Samples JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 20 SP - 8837 EP - 8842 KW - HCV KW - Genotype KW - Northeastern Thai KW - asymptomatic cases KW - blood samples DO - N2 - Background: Hepatitis C virus (HCV) infection is an important cause of liver cancer in Thailand. The highestprevalence of anti-HCV positive among Thai blood donors is found in the northeastern region. The presentanalysis of the genotype distribution among anti-HCV positive northeastern-Thai blood donors was conductedto provide a base for the epidemiological pattern of HCV infection in this region. Materials and Methods: Atotal of 112 HCV seropositive healthy blood donors were randomly selected and tested for the presence of HCVRNAby RT-PCR. HCV-RNA positive samples were genotyped by direct sequencing at core region genomes andconfirmed by phylogenetic analysis. Results: HCV viremia was found in 94.6% (106/112) of HCV seropositiveblood donors. There were 3 major genotypes distributed among this population. HCV genotype 3a was the mostprevalent (71.7%) followed by genotypes 1a (7.5%), 1b (7.5%), 6i (3.8%), 6f (2.8%) and 6n (1.9%). Conclusions:HCV genotype 3a in asymptomatic infections in northeastern Thailand is significantly higher than other previousreports. Subgenotype 6 prevalence is less than in neighboring countries and distribution patterns differ. Thefindings are relevant as predictors for using interferon therapy in this population. UR - https://journal.waocp.org/article_30004.html L1 - https://journal.waocp.org/article_30004_fc5d657d2b16b0293e70681521aa3561.pdf ER -