TY - JOUR ID - 30124 TI - Ursolic Acid Promotes Apoptosis of SGC-7901 Gastric Cancer Cells through ROCK/PTEN Mediated Mitochondrial Translocation of Cofilin-1 JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 22 SP - 9593 EP - 9597 KW - ursolic acid KW - Apoptosis KW - ROCK/PTEN KW - cofilin-1 KW - mitochondrial translocation KW - Gastric cancer DO - N2 - Ursolic acid, extracted from the traditional Chinese medicine bearberry, can induce apoptosis of gastriccancer cells. However, its pro-apoptotic mechanism still needs further investigation. More and more evidencedemonstrates that mitochondrial translocation of cofilin-1 appears necessary for the regulation of apoptosis.Here, we report that ursolic acid (UA) potently induces the apoptosis of gastric cancer SGC-7901 cells. Furthermechanistic studies revealed that the ROCK1/PTEN signaling pathway plays a critical role in UA-mediatedmitochondrial translocation of cofilin-1 and apoptosis. These findings imply that induction of apoptosis by ursolicacid stems primarily from the activation of ROCK1 and PTEN, resulting in the translocation of cofilin-1 fromcytoplasm to mitochondria, release of cytochrome c, activation of caspase-3 and caspase-9, and finally inducingapoptosis of gastric cancer SGC-7901 cells. UR - https://journal.waocp.org/article_30124.html L1 - https://journal.waocp.org/article_30124_028f3849892884fe2f38585ec5ec15fb.pdf ER -