TY - JOUR ID - 30278 TI - Association between a p73 Gene Polymorphism and Genetic Susceptibility to Non-small Cell Lung Cancer in the South of China JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 23 SP - 10387 EP - 10391 KW - NSCLC KW - p73 gene polymorphism KW - HRM and PCR-CTPP DO - N2 - Background: This study aimed to identify any association between the p73 gene G4C14-to-A4T14 polymorphismand risk of non-small cell lung cancer (NSCLC) in the south of China. Materials and Methods: We genotypedthe p73 gene polymorphism of peripheral blood DNA from 168 patients with NSCLC and 195 normal controlsusing HRM (high resolution melting) and PCR-CTPP (polymerase chain reaction with confronting two-pairprimers). Results: The results of genotyping by HRM and PCR-CTPP were consistent with direct sequencing,the p73 genotype distribution in 168 lung cancer patients being as follows: GC/GC 101 cases (60.1%), GC/AT 59 cases (35.1%), AT/AT 8 cases (4.8%). The carriers of AT/AT genotype had a significantly reduced riskof NSCLC (OR=0.370; 95%CI: 0.170-0.806; p=0.010) as compared with non-carriers. However, we found norelations between p73 genotypes and histological type (p=0.798, x2=0.452), tumor stage (p=0.806, x2=0.806), orlymph node metastasis (p=0.578, x2=1.098). Conclusions: Our findings suggest that the p73 G4C14-to-A4T14polymorphism may be a modifier of NSCLC susceptibility in the Chinese population. UR - https://journal.waocp.org/article_30278.html L1 - https://journal.waocp.org/article_30278_bc1d0c1b3b5d1f9e5604cf9bd7bb0caa.pdf ER -