TY - JOUR ID - 30634 TI - Increased UGT1A3 and UGT1A7 Expression is Associated with Pancreatic Cancer JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2015 PY - 2015 VL - 16 IS - 4 SP - 1651 EP - 1655 KW - UGT1A3 KW - UGT1A7 KW - Expression KW - Pancreatic cancer DO - N2 - UGT1A play important roles in the glucuronidation of a variety of endogenous and exogenous compounds.UGT1A isoforms are expressed tissue specifically. The aim of this study was to examine the relationship betweenUGT1A3 and UGT1A7 mRNA expression and pancreatic cancer. Paired healthy and tumor tissue samples of43 patients with pancreatic cancer were included in this study. UGT1A3 and UGT1A7 mRNA expressions wereanalyzed by real time-PCR. In the result of study, UGT1A3 and UGT1A7 mRNA expressions were significantlyhigher in tumor tissue than normal tissue of pancreatic cancer patients (p<0.05). In addition, high mRNAexpression of UGT1A3 and UGT1A7 was significantly associated with larger tumor size (p<0.05). The datasuggested that UGT1A3 and UGT1A7 may play roles in the progression of pancreatic cancer. Consequently,UGT1A3 and UGT1A7 are potential prognostic indicators. UR - https://journal.waocp.org/article_30634.html L1 - https://journal.waocp.org/article_30634_fc12abe3b02e049203f2cb40f87dfa9f.pdf ER -