TY - JOUR ID - 30747 TI - Curcumol Induces Apoptosis in SPC-A-1 Human Lung Adenocarcinoma Cells and Displays Anti-neoplastic Effects in Tumor Bearing Mice JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2015 PY - 2015 VL - 16 IS - 6 SP - 2307 EP - 2312 KW - Curcumol KW - Anti-proliferation KW - Apoptosis KW - Lung Adenocarcinoma KW - tumor bearing mice DO - N2 - Curcumol is a sesquiterpene originally isolated from curcuma rhizomes, a component of herbal remediescommonly used in oriental medicine. Its beneficial pharmacological activities have attract significant interestrecently. In this study, anti-cancer activity of curcumol was examined with both in vitro and in vivo models. It wasfound that curcumol exhibited time- and concentration-dependent anti-proliferative effects in SPC-A-1 humanlung adenocarcinoma cells with cell cycle arrest in the G0/G1 phase while apoptosis-induction was also confirmedwith flow cytometry and morphological analyses. Interestingly, curcumol did not display growth inhibition inMRC-5 human embryonic lung fibroblasts, suggesting the anti-proliferative effects of curcumol were specific tocancer cells. Anti-neoplastic effects of curcumol were also confirmed in tumor bearing mice. Curcumol (60 mg/kg daily) significantly reduced tumor size without causing notable toxicity. In conclusion, curcumol appears afavorable anti-cancer candidate for further development. UR - https://journal.waocp.org/article_30747.html L1 - https://journal.waocp.org/article_30747_4aa3cff96c4a68e48f1d9c1945fccc36.pdf ER -