TY - JOUR ID - 30839 TI - IL-35 Over-expression is Associated with Genesis of Gastric Cancer JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2015 PY - 2015 VL - 16 IS - 7 SP - 2845 EP - 2849 KW - IL-35 KW - Gastric cancer KW - Ki-67 KW - Bcl-2 DO - N2 - Overexpression of interleukin (IL)-35 has been found in a variety of malignancies, but the expression statusin gastric cancer has yet to be elucidated clearly. In the present study, positive expression of EBI3 and p35 was63.3% and 70.0% of cases, respectively. EBI3 expression was strongly related with larger tumor size and invasiondepth (P <0.05). Similarly, expression of p35 was also correlated with larger tumor size (P <0.05). These resultsindicate that IL-35 might be involved in growth of gastric cancer. Interestingly, EBI3 and p35 expressions werepositive correlated with Ki-67 expression. Moreover, EBI3 immunoreactivity was associated with Bcl-2 staining.Our data suggest IL-35 is correlated with genesis of gastric cancer by regulating growth and apoptosis. UR - https://journal.waocp.org/article_30839.html L1 - https://journal.waocp.org/article_30839_366b81062036c8cee8243d555461e8b0.pdf ER -