TY - JOUR ID - 32379 TI - VEGFR2 Expression in Head and Neck Squamous Cell Carcinoma Cancer Cells Mediates Proliferation and Invasion JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Xu, Hui-Min AU - Zhu, Jian-Guo AU - Gu, Lian AU - Hu, Song-Qun AU - Wu2, Hao AD - Department of Otolaryngology-Head and Neck Surgery, Changshu No.1 People's Hospital Affiliated to Soochow University, Changshu, China AD - Y1 - 2016 PY - 2016 VL - 17 IS - 4 SP - 2217 EP - 2221 DO - N2 - Vascular endothelial growth factor 2 (VEGFR2) was initially identified as a receptor of VEGF on endothelial cells with a role in regulating angiogenesis during organism development and tumorigenesis. Previously, in cancer tissue, VEGFR2 has been reported to be expressed in endothelial cells. In our research, we found that VEGFR2 was expressed not only in endothelial cells but also cancer cells in head and neck squamous cell carcinomas (HNSCCs). Knockdown of VEGFR2 in Hep2 cells could arrest the cell cycle in G0/G1, leading to a decrease in proliferation. We also present evidence that MAPK/ERK signal pathways and expression of CDK1 downstream of VEGFR2 might regulate proliferation and cell cycle arrest. Furthermore, we discovered that down-regulate VEGRF2 in Hep2 cells could significantly affect the invasion ability. Taken together, our data suggest that VEGFR2 might regulate proliferation and invasion in HNSCC cancer cells in vivo. UR - https://journal.waocp.org/article_32379.html L1 - https://journal.waocp.org/article_32379_154b4090181892c3e1fa592ab8c87442.pdf ER -