TY - JOUR ID - 32435 TI - Right-Sided and Left-Sided Colon Cancers are Two Distinct Disease Entities: an Analysis of 200 Cases in Pakistan JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Hussain, Mudassar AU - Waqas, Omer AU - Hassan, Usman AU - Loya, Asif AU - Akhtar, Noreen AU - Mushtaq, Sajid AU - Yusuf, Muhammad Aasim AU - Syed, Aamir Ali AD - Department of Pathology, Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan AD - Y1 - 2016 PY - 2016 VL - 17 IS - 5 SP - 2545 EP - 2548 DO - N2 - Background: There is growing evidence that there are differences in histological and genetic characteristics along with clinical behavior between right- and left-sided colon carcinomas. We have compared various parameters of the two types and assessed associations of the results with prognosis in patients in Pakistan. Materials and Methods: We reviewed 200 cases from our institutional database; 100 cases of right-sided and 100 cases of left-sided colon cancer. Parameters including age, gender, TNM stage, histological features and clinical outcome were analyzed. Results: The patients with right-sided colon cancer were significantly older as compared to their counterparts with left-sided cancer. They presented with a lumbar mass rather than symptoms of obstruction and perforation as seen in left-sided colon cancers, and the histology showed higher percentage of poorly differentiated tumors with advanced pT stage. Moreover, Crohn's-like reactions, intra tumoral lymphocyte responses and other poor prognostic factors like lymph vascular invasion and perineural invasion were more common in right-sided cancers. Conclusions: We found that right- and left-sided colon cancers are different from each other in terms of clinical presentation, histology and clinical behavior. Right-sided colon cancers are more aggressive and are associated with poorer clinical outcome as compared to left sided colon cancers in our population. UR - https://journal.waocp.org/article_32435.html L1 - https://journal.waocp.org/article_32435_d8a0bb5aeda6ac5881527c7c147ea0f6.pdf ER -