TY - JOUR ID - 32453 TI - Prevalence of IDH1/2 Mutations in Different Subtypes of Glioma in the North-East Population of Morocco JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Senhaji, Nadia AU - Louati, Sara AU - Chbani, Laila AU - Bardai, Sanae El AU - Mikou, Karima AU - MAAROUFI, Mustafa AU - Benzagmout, Mohammed AU - Faiz, Mohammed Chaoui El AU - Marie, Yannick AU - Mokhtari, Karima AU - Idbaih, Ahmed AU - Amarti, Afaf AU - Bennis, Sanae AD - Groupe Hospitalier Pitie-Salpetriere, Laboratoire de Neuropathologie R Escourolle, Paris, France AD - Y1 - 2016 PY - 2016 VL - 17 IS - 5 SP - 2649 EP - 2653 DO - N2 - Background: Genetic alterations in gliomas have increasing importance for classification purposes. Thus, we are especially interested in studying IDH mutations which may feature potential roles in diagnosis, prognosis and response to treatment. Our aim was to investigate IDH mutations in diffuse glioma patients diagnosed in university hospital centre of Fez in Morocco. Materials and Methods: IDH1 codon 132 and IDH2 codon 172 were direct-sequenced in 117 diffuse glioma samples diagnosed and treated in University Hospital Hassan II between 2010 and 2014. Results: The R132H IDH1 mutation was identified in 43/117 tumor samples and R172K IDH2 mutation was detected in only one anaplastic oligodendroglioma. IDH mutations were observed in 63.2% of astrocytomas, 73.3% of diffuse oligodendrogliomas and 12.90% of glioblastomas. Conclusions: Our results confirmed other studies published earlier for other populations with some small discrepancies. UR - https://journal.waocp.org/article_32453.html L1 - https://journal.waocp.org/article_32453_01a977b2514bc7dd2058ff154ea8c25b.pdf ER -