TY - JOUR ID - 32491 TI - Prostate Cancer, High Cortisol Levels and Complex Hormonal Interaction JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Fabre, Bibiana AU - Grosman, Halina AU - Gonzalez, Diego AU - Machulsky, Nahuel Fernandez AU - Repetto, Esteban M AU - Mesch, Viviana AU - Lopez, Miguel Angel AU - Mazza, Osvaldo AU - Berg, Gabriela AD - Clinical Biochemistry Department, INFIBIOC, Facultad de Farmacia y Bioquimica. Universidad de Buenos Aires Email : brfabre2000@yahoo.com AD - Y1 - 2016 PY - 2016 VL - 17 IS - 7 SP - 3167 EP - 3171 DO - N2 - Prostate cancer (PCa) is one of the most common diseases in men. It is important to assess prognostic factors and whether high cortisol levels and complex hormonal interactions could be responsible for PCa development. We evaluated the relationship between cortisol, leptin and estrogens in 141 men, 71 with PCa and the remaining 70 constituting a low risk group (LRG). They were recruited for this study from a total of 2906 middleaged men (ages 4570 years) who completed an evaluation for prostatic diseases at the Urology Division, Hospital de Clinicas "Jose de San Martin", University of Buenos Aires, in May 2009. In this cross sectional study, cortisol, PSA, totaltestosterone, freetestosterone, bioavailable testosterone, LH and estradiol were measured in serum. We observed increased cortisol levels in PCa patients as compared to LRG cases (p0.004,). Leptin and estradiol levels were also higher in PCa patients (p0.048; p<0.0001, respectively). Logistic regression analysis indicated that serum cortisol (OR: 1.110 (95% CI 1.0161.213), p0.022), estradiol (OR: 1.044 (95% CI 1.0081.081), p0.016) and leptin (OR: 1.248 (95% CI 1.0481.487), p0.013) explained 27% of the variance of dependent variables, even after adjusting for age, smoking, BMI and waist circumference. We found increased cortisol levels in PCa patients as compared to LRG, as well as an altered circulating hormonal profile. UR - https://journal.waocp.org/article_32491.html L1 - https://journal.waocp.org/article_32491_e6b94d668bc0685fc520f226e4e5f3a2.pdf ER -