TY - JOUR ID - 32529 TI - Calpeptin Prevents Malignant Pleural Mesothelioma Cell Proliferation via the Angiopoietin1/Tie2 System JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Tabata, Chiharu AU - Tabata, Rie AU - Nakano, Takashi AD - Cancer Center, Hyogo College of Medicine, Hyogo, Japan Email : ctabata@hyomed.ac.jp AD - Y1 - 2016 PY - 2016 VL - 17 IS - 7 SP - 3405 EP - 3409 DO - N2 - Malignant pleural mesothelioma (MPM), an aggressive malignant tumor of mesothelial origin associated with asbestos exposure, shows a limited response to conventional chemotherapy and radiotherapy. Therefore, the overall survival of MPM patients remains very poor. Progress in the development of therapeutic strategies for MPM has been limited. We recently reported that the calpain inhibitor, calpeptin exerted inhibitory effects on pulmonary fibrosis by inhibiting the proliferation of lung fibroblasts. In the present study, we examined the preventive effects of calpeptin on the cell growth of MPM, the origin of which is mesenchymal cells, similar to lung fibroblasts. Calpeptin inhibited the proliferation of MPM cells, but not mesothelial cells. It also prevented 1) the expression of angiopoietin (Ang)1 and Tie2 mRNA in MPM cells, but not mesothelial cells and 2) the Ang1induced proliferation of MPM cells through an NFkB dependent pathway, which may be the mechanism underlying the preventive effects of calpeptin on the growth of MPM cells. These results suggest potential clinical use of calpeptin for the treatment of MPM. UR - https://journal.waocp.org/article_32529.html L1 - https://journal.waocp.org/article_32529_d4c8571f44ca3bd3e67c6ecfcd0be751.pdf ER -