TY - JOUR ID - 41322 TI - Association of lnc-LAMC2-1:1 rs2147578 and CASC8 rs10505477 Polymorphisms with Risk of Childhood Acute Lymphoblastic Leukemia JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Hashemi, Mohammad AU - Bahari, Gholamreza AU - Naderi, Majid AU - Sadeghi-Bojd, Simin AU - Taheri, Mohsen AD - Zahedan University of Medical Sciences Y1 - 2016 PY - 2016 VL - 17 IS - 11 SP - 4985 EP - 4989 KW - long non-coding RNA KW - lnc-LAMC2-1:1 KW - CASC8 KW - Acute Lymphoblastic Leukemia KW - Polymorphism DO - 10.22034/APJCP.2016.17.11.4985 N2 -   Long non-coding RNAs (lncRNAs) are a novel class of non-protein coding RNAs that are involved in a wide variety of biological processes. There are limited data regarding the impact of lnc-LAMC2-1:1 rs2147578 as well as CASC8 rs10505477 T>C polymorphisms on cancer development. Here we examined for the first time whether rs2147578 and rs10505477 polymorphisms are associated with childhood acute lymphoblastic leukemia (ALL) in a total of 110 cases and 120 healthy controls. Genotyping was achieved by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The rs2147578 variant increased the risk of ALL in codominant (OR=4.33, 95%CI=2.00-9.37, p<0.0001, CG vs CC, and OR=5.81, 95%CI=2.30-14.69, p=0.0002, GG vs CC), dominant (OR=4.63, 95%CI=2.18-9.86, p<0.0001, CG+GG vs CC), overdominant (OR=1.74, 95%CI=1.02-2.97, p=0.0444, CG vs CC+GG) and allele (OR=1.91, 95%CI=1.32-2.77, p=0.0008, G vs C) inheritance models tested. No significant association was found between the CASC8 rs10505477 T>C variant and risk of childhood ALL. In conclusion, the present study revealed that the lnc-LAMC2-1:1 rs2147578 polymorphism may be a risk factor for developing childhood ALL. Further studies with larger sample sizes with different ethnicities are now required to confirm our findings. UR - https://journal.waocp.org/article_41322.html L1 - https://journal.waocp.org/article_41322_9968725746dd31d9a278e531b8b91fa7.pdf ER -