TY - JOUR ID - 44652 TI - Dosimetric Comparison of Three Different Radiotherapy Techniques in Antrum-Located Stomach Cancer JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Serarslan, Alparslan AU - Ozbek Okumus, Nilgun AU - Gursel, Bilge AU - Meydan, Deniz AU - Dastan, Yalcin AU - Aksu, Talat AD - Department of Radiation Oncology, Faculty of Medicine, Ondokuz Mayis University,Samsun, Turkey Y1 - 2017 PY - 2017 VL - 18 IS - 3 SP - 741 EP - 746 KW - conformal radiotherapy KW - Dosimetry KW - field-in-field radiotherapy KW - intensity-modulated radiotherapy KW - stomach cancer DO - 10.22034/APJCP.2017.18.3.741 N2 -   Background: The current optimal radiotherapy (RT) planning technique for stomach cancer is controversial. The design of RT for stomach cancer is difficult and differs according to tumor localization. Dosimetric and clinical studies have been performed in patients with different tumor localizations. This may be the main source of inconsistencies in study results. For this reason, we attempted to find the optimal RT technique for patients with stomach cancer in similar locations. Methods: This study was based on the computed tomography datasets of 20 patients with antrum-located stomach cancer. For each patient, treatments were designed using physical wedge-based conformal RT (WB-CRT), field-in-field intensity-modulated RT (FIF-IMRT), and dynamic intensity-modulated RT (IMRT). The techniques were compared in terms of expected target volume coverage and the dose to organs at risk (OAR) using a dose-volume histogram analysis. Results: FIF-IMRT was the most homogenous technique, with a better homogeneity index than WBCRT (p<0.001) or IMRT (p<0.001). However, IMRT had a better conformity index than WBCRT (p<0.001) or FIF-IMRT (p<0.001). Additionally, all OAR, including the kidneys, liver, and spinal cord, were better protected with IMRT than with WBCRT (p=0.023 to <0.001) or FIF-IMRT (p=0.028 to <0.001). Conclusions: In comparison to FIF-IMRT and WBCRT, IMRT appears to be the most appropriate technique for antrum-located stomach cancer. To establish whether IMRT is superior overall will require clinical studies, taking into account differences in both tumor localization (cardia, body, and antrum) and organ movement in patients with stomach cancer. UR - https://journal.waocp.org/article_44652.html L1 - https://journal.waocp.org/article_44652_3ae21eeaefc07a7420517966dfd62c68.pdf ER -