TY - JOUR ID - 46066 TI - Lack of Association of the Fat Mass and Obesity Associated (FTO) Gene rs9939609 Polymorphism with Breast Cancer Risk: a Systematic Review and Meta-Analysis Based on Case - Control Studies JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Jafari-Nedooshan, Jamal AU - Kargar, Saeed AU - Neamatzadeh, Hossein AU - Haghighi, Fatemeh AU - dehghani, reihaneh AU - Seddighi, Niloofar AD - Department of General Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran AD - Department of Medical Genetics,Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Y1 - 2017 PY - 2017 VL - 18 IS - 4 SP - 1031 EP - 1037 KW - breast cancer KW - FTO rs9939609 KW - Polymorphism KW - risk KW - Meta-analysis DO - 10.22034/APJCP.2017.18.4.1031 N2 -   Background: Previously published data on any association of the fat mass and obesity-associated (FTO) gene with breast cancer risk remain inconclusive. Therefore, we conducted the present meta-analysis of links between breast cancer and the FTO rs9939609 polymorphism. Methods: We have conducted a systematic review of the English literature by searching PubMed, Google Scholar and ISI Web of Knowledge databases for studies on associations between the FTO rs9939609 polymorphism and breast cancer risk. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association using fixed- or random-effects model. Results: We included five studies with 1134 cases and 1453 controls. Overall, no significant association between the FTO rs9939609 polymorphism and risk of breast cancer was found. On subgroup analysis by ethnicity, there was still no significant association detected. Conclusions: To our knowledge, this is the first meta-analysis of the FTO rs9939609 polymorphism and risk of breast cancer. However, the present meta-analysis suggested that only there might be a significant association of the CXCL12 rs1801157 polymorphisms with breast cancer risk. UR - https://journal.waocp.org/article_46066.html L1 - https://journal.waocp.org/article_46066_f9a7c1809fab90c61b14eb2cfc89b53a.pdf ER -