TY - JOUR ID - 46091 TI - ‘Mate’ Intake, Hormone-Based Risk Factors and Breast Cancer: a Case-Control Study JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Ronco, Alvaro L AU - Espinosa, Edison AU - Calderon, Juan M AU - Lasalvia Galante, Eduardo AU - De Rosa, Alejandro AU - Sanchez, Gustavo AD - Unit of Oncology and Radiotherapy, Pereira Rossell Women's Hospital, Bvar.Artigas 1550, Montevideo 11300, Uruguay. AD - Biomedical Sciences Center, University of Montevideo, Puntas de Santiago 1604, Montevideo 11600, Uruguay. AD - IUCLAEH School of Medicine, Prado and Salt Lake, Maldonado 20100, Uruguay. AD - Endocrinology and Metabolism Department, Clinical Hospital, UdelaR State University, Av.Italia s/n y Las Heras, Montevideo 11300, Uruguay. Y1 - 2017 PY - 2017 VL - 18 IS - 4 SP - 941 EP - 948 KW - breast cancer KW - estrogens KW - ilex paraguariensis KW - maté KW - reproductive life DO - 10.22034/APJCP.2017.18.4.941 N2 - Previous reports on the inverse association between ‘mate’ intake (infusion of Ilex Paraguariensis herb) and breastcancer (BC) risk led us to consider two main roles for the infusion: as a substantial antioxidant contributor and asa hormone regulator, particularly through anti-aromatase capacities. Since menstrual-reproductive risk factors forBC reflect women’s estrogenic exposure during the reproductive lifespan, and considering that ‘mate’ intake exertsputative stronger protection among high antioxidant contributors, we attempted to analyze interactions among theinfusion, hormon-linked reproductive factors and BC risk, which have hitherto remained unexplored. We analyzed adatabase of 572 BC incident cases and 889 controls. Women were interviewed with a specific questionnaire featuringsocio-demographic, lifestyle and reproductive variables (age at menarche, 1st live birth and menopause; number of livebirths; breastfeeding months), and a food frequency questionnaire, focusing on ‘mate’ intake (consumer status, dailyintake, age at start, age at quit, duration of habit). Odds ratios (OR) and their 95% confidence Intervals were calculatedthrough unconditional logistic regression, adjusting for relevant potential confounders. ‘Mate’ intake showed stronginverse associations with some high-risk hormone-related factors: early menarche, nulliparity, low breastfeeding, longreproductive years and high number of ovulatory cycles. Moreover, all subsets of high dietary energy demonstratedeven stronger associations. In conclusion, regarding exposure to known hormone risk factors, we found strong inverseassociations between high ‘mate’ intake and BC, which were greater among those consuming higher calorific diets.Our analyses support possible combined antioxidant and antiestrogenic effects for ‘mate’ infusions. UR - https://journal.waocp.org/article_46091.html L1 - https://journal.waocp.org/article_46091_f5769f97b3b43b948ae195eb3b37943b.pdf ER -