TY - JOUR ID - 46977 TI - HOTAIR Long Noncoding RNA is not a Biomarker for Acute Myeloid Leukemia (AML) in Iranian Patients JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Sayad, Arezou AU - Hajifathali, Abbas AU - Hamidieh, Amir Ali AU - Roshandel, Elham AU - Taheri, Mohammad AD - Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Taleghani bone marrow transplantation center, Taleghani Hospital, Shahid Beheshti university of medical sciences, Tehran, Iran. AD - Pediatric Stem Cell Transplant Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AD - HSCT Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Y1 - 2017 PY - 2017 VL - 18 IS - 6 SP - 1581 EP - 1584 KW - acute myeloid leukemia KW - long non-coding RNA KW - HOTAIR DO - 10.22034/APJCP.2017.18.6.1581 N2 -   Accumulating evidence indicates that lncRNAs may have potential as new biomarkers to predict prognosis of different human cancers. HOTAIR lncRNA, transcribed from the human HOX locus, has been suggested to regulate gene expression of important target genes and up-regulation has been noted in malignancies. The role of HOX transcript antisense RNA in acute myeloid leukemia (AML) was investigated in the present case control study. HOTAIR expression was evaluated in blood samples of twenty five de novo AML patients and fifty healthy controls using real-time quantitative reverse transcription-PCR (qRT-PCR). Our results demonstrated no significant differences in HOTAIR lncRNA expression level between AML patients and healthy individuals. The obtained data indicate that HOTAIR is not an informative and reliable biomarker for AML diagnosis, although our results should be confirmed in further studies. UR - https://journal.waocp.org/article_46977.html L1 - https://journal.waocp.org/article_46977_4db1437cc78c35c0925ce79a510ae673.pdf ER -