TY - JOUR ID - 55157 TI - Prognostic Value of RUNX1 Mutations in AML: A Meta-Analysis JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Jalili, Mahdi AU - Yaghmaie, Marjan AU - Ahmadvand, Mohammad AU - Alimoghadam, Kamran AU - Mousavi, Seyed Asadollah AU - Vaezi, Mohammad AU - Ghavamzadeh, Ardeshir AD - Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran. Y1 - 2018 PY - 2018 VL - 19 IS - 2 SP - 325 EP - 329 KW - acute myeloid leukemia KW - AML1/RUNX1 mutation KW - Prognosis KW - Meta-analysis DO - 10.22034/APJCP.2018.19.2.325 N2 -   The RUNX1 (AML1) gene is a relatively infrequent mutational target in cases of acute myeloid leukemia (AML). Previous work indicated that RUNX1 mutations can have pathological and prognostic implications. To evaluate prognostic value, we conducted a meta-analysis of 4 previous published works with data for survival according to RUNX1 mutation status. Pooled hazard ratios for overall survival and disease-free survival were 1.55 (95% confidence interval (CI) = 1.11–2.15; p-value = 0.01) and 1.76 (95% CI = 1.24–2.52; p-value = 0.002), respectively, for cases positive for RUNX1 mutations. This evidence supports clinical implications of RUNX1 mutations in the development and progression of AML cases and points to the possibility of a distinct category within the newer WHO classification. Though it must be kept in mind that the present work was based on data extracted from observational studies, the findings suggest that the RUNX1 status can contribute to risk-stratification and decision-making in management of AML. UR - https://journal.waocp.org/article_55157.html L1 - https://journal.waocp.org/article_55157_9dc1dee582c51ebf6ea3c1a91dc9fdfe.pdf ER -