TY - JOUR ID - 57182 TI - Impact of Cyclin D1 and Heterogeneous Nuclear Ribonucleoprotein-K (HnRNP-K) on Urinary Bladder Carcinogenesis JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Aboushousha, Tarek AU - Hammam, Olfat AU - Helal, Noha AU - El Dahshan, Samir AD - Pathology Departments,Theodor Bilharz Research Institute, Cairo, Egypt. AD - Urology Departments, Theodor Bilharz Research Institute, Cairo, Egypt. Y1 - 2018 PY - 2018 VL - 19 IS - 2 SP - 513 EP - 519 KW - bladder cancer KW - bilharziasis KW - Cyclin D1 KW - hnRNP-K KW - immunohistochemistry DO - 10.22034/APJCP.2018.19.2.513 N2 - Objective: This study aimed to investigate the expression of cyclin D1 and hnRNP-K in relation to the pathologicalfindings in bladder cancer including the type, grade, muscle invasion and bilharzial association. Methods: We studiedthe immunoexpression; as regard the percentage, intensity and score of both cyclin D1 and hnRNP-K in different bladderlesions including 10 cases of cystitis; 10 cases of carcinoma insitu (CIS), 20 cases of Squamous cell carcinoma (SCC)and 66 cases of urothelial carcinoma (UC). Results: High expression of cyclin D1 was found in UC compared to othergroups (p<0.001) and in UC with low grade, non-muscle invasive and papillary tumors compared to their counterparts(p<0.05, hnRNP-K expression was found in SCC compared to other groups (p <0.001) and in UC with high grade, muscle invasiveand non-papillary tumors compared to their counterparts (p<0.001each). Bilharzial-associated UC showed higherexpression of hnRNP-K percent (p<0.05) compared to non-bilharzial cases. Conclusion: This study elucidated a possiblecontribution of cyclin D1 and hnRNP-K expression in the initiation and progression of urinary bladder carcinoma,so, both of them can be used in predicting progression of urinary bladder carcinoma and to differentiate between UCand SCC in high grade tumors. The possible role of both markers in immunotherapy deserves supplementary studies. UR - https://journal.waocp.org/article_57182.html L1 - https://journal.waocp.org/article_57182_1534ae6ce334389b33d761a3c5d01444.pdf ER -