TY - JOUR ID - 57449 TI - Factors Associated with Colorectal Cancer Among Jordanians: a Case- Control Study JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Khatatbeh, Moawiah M AU - Jadallah, Khaled A AU - AL Bashtawy, Mohammed AU - Hamaydeh, Suad A AU - Gharaibeh, Mays A AU - Kanaan, Nadia B AU - Alsmadi, Bara M AD - Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan. AD - Department of Internal Medicine, King Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan. AD - Princess Salma Faculty of Nursing, Al al-Bayt University, Mafraq, Jordan. Y1 - 2018 PY - 2018 VL - 19 IS - 2 SP - 577 EP - 581 KW - Case-control KW - colorectal cancer KW - Jordan KW - Lifestyle DO - 10.22034/APJCP.2018.19.2.577 N2 - Objective: In recent years, the incidence of colorectal cancer (CRC) in Jordan has been on the rise. We aimed todetermine associations with lifestyle factors, demographic and clinical variables. Methods: This case-control studyincluded 102 patients diagnosed with CRC and 198 age and gender matched healthy subjects as controls. Cases werepurposefully sampled; however, the control group were selected by simple random sampling of a cross-section of thepopulation in Northern Jordan. Participating cases and controls completed an anonymous questionnaire inquiring abouttheir demographic characteristics, lifestyle factors, and clinical variables. Data about the medical history and diagnosisof participating cases were obtained from the cases themselves and confirmed by reviewing their medical records.Results: In the cross tabulation analysis, the Chi square test showed that diabetes and hypertension were significantlyassociated with CRC (P <0.05). Additionally, regression modeling revealed that age ≥ 45 years (OR=10.93), positivefamily history for CRC (OR=5.53), physical inactivity (OR=7.4), cigarette smoking (OR=3.71), and having other typesof cancer (OR=13.61) were all associated with increased risk of CRC. Conclusions: Physical inactivity and cigarettesmoking are among the top modifiable risk factors for CRC among Jordanians. Moreover, diabetes and hypertensionwere found to be statistically significant risk factors in univariate, but not multivariate analysis. More effective strategiesfor elevating awareness and prevention are required at both national and international levels. Improving screeningstrategies is needed for early detection of CRC in Jordan. UR - https://journal.waocp.org/article_57449.html L1 - https://journal.waocp.org/article_57449_3045e382b4981faab925ea17f00dd161.pdf ER -