TY - JOUR ID - 57454 TI - AKAP4, SPAG9 and NY-ESO-1 in Iranian Colorectal Cancer Patients as Probable Diagnostic and Prognostic Biomarkers JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Tavakoli Koudehi, Ameneh AU - Mahjoubi, Bahar AU - Mirzaei, Rezvan AU - Shabani, Samira AU - Mahjoubi, Frouzandeh AD - Department of Clinical Genetics, National Institute of Genetic Engineering and Biotechnology (NIGEB),Tehran, Iran. AD - Colorectal Cancer Research Center, Hazrat Rasool Hospital, Iran University of Medical Sciences and Health Care Services, Tehran, Iran. Y1 - 2018 PY - 2018 VL - 19 IS - 2 SP - 463 EP - 469 KW - AKAP4 KW - Biomarker KW - colorectal cancer KW - NY-ESO-1 KW - SPAG9 DO - 10.22034/APJCP.2018.19.2.463 N2 - Background and objectives: Colorectal cancer (CRC) is the most common gastrointestinal cancer and the secondleading cause of cancer death in women in the world. Cancer-Testis Antigens (CTAs) are a group of tumor-associatedproteins which typically are expressed in normal reproductive cells of men, but their expression in normal somatic cellsis silenced. CTAs, due to their limited expression pattern, are considered as promising targets for cancer diagnosis andimmuno-therapy. Methods: Expression of AKAP4, SPAG9 and CTAG1B genes from the CTAs family was studiedin both tumor and normal tissues of 62 Iranian CRC patients by RT-PCR with the aim of finding biomarkers for earlydetection and anticipated progression. Statistical analysis was performed SPSS software V22.0 to assess the significanceof any associations. Results: Elevated expression of SPAG9 and AKAP4 genes was observed in approximately 66%and 44% of tumours, respectively, as compared to adjacent non-cancerous tissues. While a significant association wasfound between AKAP4 gene expression and metastasis (P-value: 0.045), expression of the CTAG1B (NY-ESO-1) genewas not observed in our cases. Conclusion: AKAP4 and SPAG9 genes may find use as diagnostic biomarkers for CRCand AKAP4 may play an important role in progression to metastasis. UR - https://journal.waocp.org/article_57454.html L1 - https://journal.waocp.org/article_57454_2c0337cca28f8fc223746e81ef426210.pdf ER -