TY - JOUR ID - 57460 TI - Genetic Polymorphism of the Glutathione S-transferase Pi 1 (GSTP1) and Susceptibility to Cervical Cancer in Human Papilloma Virus Infected Northeastern Thai Women JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Phuthong, Sophida AU - Settheetham-Ishida, Wannapa AU - Natphopsuk, Sitakan AU - Ishida, Takafumi AD - Department of Physiology, Khon Kaen University, Khon Kaen, Thailand. AD - Chulabhorn International College of Medicine, Thammasat University,, Thailand. AD - Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, 1130033, Japan. Y1 - 2018 PY - 2018 VL - 19 IS - 2 SP - 381 EP - 385 KW - glutathione S-transferase pi 1 KW - Susceptibility KW - Cervical cancer KW - Human papilloma virus DO - 10.22034/APJCP.2018.19.2.381 N2 - Objective: We aimed to investigate any association between a genetic polymorphism of the detoxification GSTP1gene and risk of cervical cancer in northeastern Thailand. Materials and Methods: Genotyping of GSTP1 was performedfor 198 squamous cell cervical cancer (SCCA) patients and 198 age-matched healthy controls with the PCR-RFLPmethod. Results: The respective frequencies of the G allele were 0.33 and 0.26 in the controls and cases, the differencebeing significant (OR = 0.69 [95% CI: 0.50-0.95, p=0.0192]). Among women infected with high-risk types of HPV, beinga heterozygous carrier was associated with a reduced risk of cervical cancer (adjusted OR = 0.32 [95% CI: 0.12-0.91,p=0.031]). Similarly, a decreased risk was observed in heterozygous women with a non-smoking partner (adjusted OR= 0.27 [95% CI: 0.09-0.83, p=0.023]). Conclusions: GSTP1 polymorphism could influence susceptibility to cervicalcancer among northeast Thai women; either as a independent factor or in combination with high-risk HPV infection.Dual-testing of HPV and the GSTP1 might prove an effective screening tool for cervical cancer. UR - https://journal.waocp.org/article_57460.html L1 - https://journal.waocp.org/article_57460_608ef7df85df4fb5a391f0b17eecf4f5.pdf ER -