TY - JOUR ID - 57579 TI - Expression of Laminin in Oral Squamous Cell Carcinomas JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Yellapurkar, Shweta AU - Natarajan, Srikant AU - Boaz, Karen AU - Manaktala, Nidhi AU - Baliga, Mohan AU - Shetty, Premalatha AU - Prasad, Mukul AU - Ravi, Mahalakshmi AD - Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences Mangalore, Manipal Academy of Higher Education, India. AD - Department of Oral and Maxillofacial Surgery, Manipal College of Dental sciences, Mangalore, Manipal Academy of Higher Education, India. Y1 - 2018 PY - 2018 VL - 19 IS - 2 SP - 407 EP - 413 KW - Laminin KW - Basement Membrane KW - OSCC KW - Prognosis DO - 10.22034/APJCP.2018.19.2.407 N2 - Background and objectives: Laminin is a significant basement membrane (BM) glycoprotein, the expression ofwhich reflects BM integrity more precisely than do other ECM proteins. The present study aimed to evaluate lamininexpression in oral squamous cell carcinomas OSCC and to determine any associations with clinico-pathologicalparameters (surgical margin status, lymph node involvement, survival and recurrence). Methods: Laminin expression wasevaluated in 31 cases of biopsy-proven OSCC by immunohistochemical staining and its association with prognosticatorsand the Brynes grading system was determined by appropriate statistical analysis. Results: We observed a significantincrease in linear staining pattern (p<0.001) at the tumour-host interface in well-differentiated OSCC cases, in contrastto poorly differentiated lesions which exhibited intense cytoplasmic expression within tumour cells. Higher cytoplasmiclaminin expression was seen in 33.3% of cases with involved surgical margins and 69.2% of cases with lymph nodemetastasis (along with weak/absent staining of laminin around the tumour-host interface – Basement membrane aroundtumour islands). Similarly, in 60% of the cases who died and in 81.8% of cases with tumour recurrence, moderatelyintense cytoplasmic laminin expression was seen within tumour cells. On comparing variables of the Brynes gradingsystem, significant cytoplasmic expression of laminin was linked with mild inflammation (p<0.0016) and increasedmitotic activity (p<0.008). Conclusion: Based on these observations, immunohistochemical expression of lamininmight be useful to evaluate histological differentiation and aggressiveness of OSCCs. UR - https://journal.waocp.org/article_57579.html L1 - https://journal.waocp.org/article_57579_4b578c3ce836c8b56ac5a1a0d98919c4.pdf ER -