TY - JOUR ID - 57699 TI - Significant SNPs Related to Telomere Length and Hepatocellular Carcinoma Risk in Chronic Hepatitis B Carriers JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Mohamadkhani, Ashraf AU - Pourasgari, Masome AU - Poustchi, Hossein AD - Liver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. AD - Cell and Molecular Biology Department, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran. Y1 - 2018 PY - 2018 VL - 19 IS - 3 SP - 585 EP - 590 KW - Chronic Hepatitis B (CHB) KW - hepatocellular carcinoma (HCC) KW - SNPs KW - Telomere Length KW - SNPnexus DO - 10.22034/APJCP.2018.19.3.585 N2 - Chronic hepatitis B virus (HBV) infection increases the risk of developing cirrhosis and hepatocellular carcinoma(HCC) with suspected interactions between virus replication and host immune responses. A number of reports havesuggested that telomerase function may be involved in chronic hepatitis B (CHB) pathogenesis, but positive or negativeassociations with HCC risk remain for discussion. Mean telomere length is an indicator of biological aging and it hasbeen reported that reduction in NBV carriers compared to normal individuals. In somatic cells, telomeres containsimple, tandemly repeated G-rich sequences that frequently are reduced by 50 to 200 base pairs at each cell division.Several genome-wide association studies (GWAS) in diverse ethnic populations have revealed eleven single nucleotidepolymorphisms (SNPs) linked to telomere length. Two of these, rs398652 and rs621559, have prognostic value and couldbe used as genetic markers. This review describes current knowledge concerning telomerase activity and telomere lengthas well as significant polymorphisms in HBV-related HCC patients. In particular, to cast light on genotype-phenotypeinteractions, we used SNPnexus to evaluate effects of the two SNPs on risk of disease and complex disorders. UR - https://journal.waocp.org/article_57699.html L1 - https://journal.waocp.org/article_57699_834bfb93bdc4706d16e046e1a4d3ec45.pdf ER -