TY - JOUR ID - 57703 TI - Comparative Evaluation of a 6MV Flattened Beam and a Flattening Filter Free Beam for Carcinoma of Cervix – IMRT Planning Study JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Tamilarasu, Suresh AU - Saminathan, Madeswaran AU - Sharma, SK AU - Pahuja, Anjali AU - Dewan, Abhinav AD - Department of Radiotherapy, Rajiv Gandhi Cancer Institute and Research Centre, Rohini, New Delhi, India. AD - Department of Physics, VIT University, Vellore, Tamil Nadu, India. Y1 - 2018 PY - 2018 VL - 19 IS - 3 SP - 639 EP - 643 KW - Intensity modulated Radiotherapy KW - Flatten beam KW - Flattening filter free photon beam KW - Secondary cancer risk DO - 10.22034/APJCP.2018.19.3.639 N2 - Purpose: Intensity modulated radiotherapy (IMRT) plan quality, beam on time and integral dose were compared using6MV FB (Flattened Beam) and FFFB (Flattening filter free beam) for carcinoma of cervix. Materials and Methods:Ten patients with stage II–IIIB cervix cancer (Ca.Cx) were retrospectively identified from the department database.Target volume (TV) and organ at risk (OAR) were delineated as per Radiation Therapy Oncology Group (RTOG) cancerguidelines. Dose prescribed to planning target volume (PTV) was 50.4Gy in 28 fractions. Two plans (6MV FB IMRTand 6MV FFFB IMRT) were generated to achieve 95% of prescription dose to PTV and sparing OAR as per normaltissue guidelines. Numbers of beams and their orientations were the same for all plans. The homogeneity index (HI),conformity index (CI), treatment monitor unit (MU), beam on time (BOT) and non-tumor integral dose (NTID) werechosen for comparison. Results: FFFB generated plans were clinically acceptable. There was a statistically significantdifference among the FB IMRT and FFFB IMRT plans with respect to CI, HI, D50%, D2% in PTV coverage, bladderV50Gy, MU, mean NTID and non-tumor low dose volume. Conclusions: 6MV flattened and flattening filter free photonbeams produce comparable plans by IMRT . FFF beams allow time efficient treatment delivery and may help reducethe risk of secondary malignances in carcinoma cervix cases. UR - https://journal.waocp.org/article_57703.html L1 - https://journal.waocp.org/article_57703_4a15cf8240b7c3db7a582e7e828e08a6.pdf ER -