TY - JOUR ID - 57745 TI - Osteopontin b and c Splice isoforms in Leukemias and Solid Tumors: Angiogenesis Alongside Chemoresistance JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Mirzaei, Akram AU - Mohammadi*, Saeed AU - Ghaffari, Seyed Hamid AU - Yaghmaie, Marjan AU - Vaezi, Mohammad AU - alimoghaddam, kamran AU - Ghavamzadeh, Ardeshir AD - Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran. Y1 - 2018 PY - 2018 VL - 19 IS - 3 SP - 615 EP - 623 KW - Osteopontin KW - Splice isoforms KW - Leukemia KW - Solid Tumor KW - Angiogenesis DO - 10.22034/APJCP.2018.19.3.615 N2 - Osteopontin (OPN) is a glycoprotein involved in regulation of various influences on tumor progression, such ascellular proliferation, apoptosis, angiogenesis, and metastasis. Vascular endothelial growth factor (VEGF) is a secretedmolecule supporting angiogenesis in various cancers through activation of the PI3K/AKT/ERK1/2 pathway. OPN andVEGF have a number of isoforms with various activities. In spite of the well-defined association between OPN andVEGF isoform expression and cure rate for solid tumors, there is a scarcity of information as to any association inleukemia. Based on the critical role of OPN in cell survival, it seems reasonable to hypothesize that OPN and VEGFisoform expression levels may impact on chemoresistance and relapse in leukemia the same as in solid tumors. Hence,the aim of our review was to explain relationships between OPN and VEGF isoforms and angiogenesis and relatedpathways in chemoresistance of leukemia and solid tumors. Our findings demonstrated that OPNb and OPNc alongsidewith VEGF isoforms and other gene pathways are involved in angiogenesis and also might promote chemoresistanceand even recurrence in leukemia and solid tumors. To sum up, targeting OPN isoforms, particularly b and c, might bea novel therapeutic strategy for the treatment of leukemia as well as solid tumors. UR - https://journal.waocp.org/article_57745.html L1 - https://journal.waocp.org/article_57745_bf923cc940b707c1b3b49339b2a2e513.pdf ER -