TY - JOUR ID - 58431 TI - Contrast-Enhanced Perfusion MR Imaging to Differentiate Between Recurrent/Residual Brain Neoplasms and Radiation Necrosis JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Metaweh, Noha Ahmed Kamal AU - Azab, Amr Osama AU - EL Basmy, Ayman Abd El Hameed AU - Mashhour, Karim Nabil AU - EL Mahdy, Wael Mokhtar AD - Radiology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. AD - Kasr El-Ainy Center of Clinical Oncology, Cairo University, Cairo, Egypt. AD - Department of Neurosurgery, Faculty of Medicine, Cairo University, Cairo, Egypt. Y1 - 2018 PY - 2018 VL - 19 IS - 4 SP - 941 EP - 948 KW - Dynamic susceptibility contrast enhanced MR Perfusion KW - Recurrent brain tumors KW - Radiation necrosis DO - 10.22034/APJCP.2018.19.4.941 N2 - Purpose: To determine the value of dynamic susceptibility contrast enhanced (DSC) MRI (magnetic resonance imaging)perfusion in the characterization of newly developed/enlarging lesions within irradiated regions after treatment of braintumors. Methods: This prospective cross-sectional study covered 23 patients, 12 females and 11 males. All casesinitially presented with histologically proven malignant brain tumors and underwent surgical intervention followed byradiotherapy (+/- chemotherapy). On follow up imaging, they presented with newly developed/progressively enhancingmass lesions at the sites of the primary tumors. All patients then underwent conventional MRI, DSC MRI perfusionand MR spectroscopy. Results: In our study, we found DSC MR perfusion to be a useful non-invasive method fordifferentiating recurrent brain tumors from radiation necrosis. This approach allows hemodynamic measurements tobe obtained within the brain as the relative cerebral blood volume (rCBV) to complement the anatomic informationobtained with conventional contrast enhanced MR imaging. The sensitivity and specificity of DSC MR perfusionfor differentiation were found to be 77.8% and 80.0%, respectively. Conclusion: DSC MR perfusion is a promisingtechnique in differentiating recurrent brain tumors from radiation necrosis as it has acceptable spatial resolution andcan be routinely performed in the same settings after conventional MRI. UR - https://journal.waocp.org/article_58431.html L1 - https://journal.waocp.org/article_58431_dc6696b942f58c9c13830061d2746f7d.pdf ER -