TY - JOUR ID - 66087 TI - Pooled Analysis of the Associations between Body Mass Index, Total Cholesterol, and Liver Cancer-related Mortality in Japan JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Ukawa, Shigekazu AU - Tamakoshi, Akiko AU - Murakami, Yoshitaka AU - Kiyohara, Yutaka AU - Yamada, Michiko AU - Nagai, Masato AU - Satoh, Atsushi AU - Miura, Katsuyuki AU - Ueshima, Hirotsugu AU - Okamura, Tomonori AU - Research Group, EPOCH-JAPAN AD - Department of Public Health, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido, Japan. AD - Department of Medical Statistics, Toho University Faculty of Medicine, Tokyo, Japan. AD - Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. AD - Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan. AD - Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan. AD - Department of Preventive Medicine and Public Health, Fukuoka University, Fukuoka, Japan. AD - Department of Public Health, Shiga University of Medical Science, Shiga, Japan. AD - Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan. AD - Y1 - 2018 PY - 2018 VL - 19 IS - 8 SP - 2089 EP - 2095 KW - Obesity KW - Cholesterol KW - Body mass index KW - Liver cancer KW - pooled-analysis DO - 10.22034/APJCP.2018.19.8.2089 N2 - Objective: We employed a large-scale pooled analysis to investigate the association of liver cancer-relatedmortality with being overweight/obese and total cholesterol (TC) levels, since limited and inconsistent data on theseassociations exist in Japan. Methods: A total of 59,332 participants (23,853 men and 35,479 women) from 12 cohortswithout a history of cancer who were followed for a median of 14.3 years were analyzed. A sex-specific stratifiedCox proportional hazards model adjusted for age and other potential confounders was used to calculate hazard ratios(HRs) and 95% confidence intervals (CI) for liver cancer-related mortality. Results: A total of 447 participants(266 men and 181 women) died of liver cancer within the follow-up period. Individuals classified as having a highBMI (≥25.0 kg/m2) and low TC levels (mortality (HR 7.05, 95% CI 4.41–11.26 in men; HR 8.07, 95% CI 4.76–13.67 in women) when compared with thosein the intermediate BMI (18.5–24.9 kg/m2) and TC (160–219 mg/dL) categories. These associations remained afterlimiting the follow-up duration to >5 years. Conclusion: Being overweight/obese, combined with low TC levels, wasstrongly associated with liver cancer-related mortality in the EPOCH-JAPAN. UR - https://journal.waocp.org/article_66087.html L1 - https://journal.waocp.org/article_66087_f98bbd39f50cf015609f9f719bdb4b18.pdf ER -