TY - JOUR ID - 66140 TI - Main Risk Factors Association with Proto-Oncogene Mutations in Colorectal Cancer JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Dolatkhah, Roya AU - Somi, Mohammad Hossein AU - Shabanloei, Reza AU - Farassati, Faris AU - Fakhari, Ali AU - Dastgiri, Saeed AD - Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. AD - Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. AD - Department of Medical- Surgical Nursing, Nursing and Midwifery Faculty, Tabriz University of Medical Sciences, Tabriz, Iran. AD - The University of Kansas Medical School-Molecular Medicine Laboratory, Kansas City, KS, USA. AD - Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Y1 - 2018 PY - 2018 VL - 19 IS - 8 SP - 2183 EP - 2190 KW - colorectal cancer KW - risk factors KW - KRAS KW - Regression DO - 10.22034/APJCP.2018.19.8.2183 N2 - Objective: Although several factors have been shown to have etiological roles in colorectal cancer, few investigationshave addressed how and to what extent these factors affect the genetics and pathology of the disease. Precise relationshipswith specific genetic mutations that could alter signaling pathways involved in colorectal cancer remain unknown.We therefore aimed to investigate possible links between lifestyle, dietary habits, and socioeconomic factors and specificmutations that are common in colorectal cancers. Methods: Data were retrieved from a baseline survey of lifestyle factors,dietary behavior, and SES, as well as anthropometric evaluations during a physical examination, for 100 confirmedprimary sporadic colorectal cancer patients from Northwest Iran. Results: High socioeconomic status was significantlyassociated with higher likelihood of a KRAS gene mutation (P < 0.05) (odds ratio: 3.01; 95% CI: 0.69–13.02). Consumingcarbohydrates and alcohol, working less, and having a sedentary lifestyle also increased the odds of having a KRASmutation. Conclusion: Although research has not yet described the exact relationships among genetic mutations withdifferent known risk factors in colorectal cancer, examples of the latter may have an impact on KRAS gene mutations. UR - https://journal.waocp.org/article_66140.html L1 - https://journal.waocp.org/article_66140_7cffbe6b6734f7ac9e592845b729f0a4.pdf ER -