TY - JOUR ID - 77415 TI - Risk Factors and Prognosis of Spontaneously Ruptured Hepatocellular Carcinoma in Thailand JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Kerdsuknirun, Jitrapa AU - Vilaichone, Virunpat AU - Vilaichone, Ratha-Korn AD - Gastroenterology Unit, Department of Medicine, Faculty of Medicine, Thammasat University Hospital, Pathumthani, Thailand. AD - Patumwan Demonstration School, Srinakharinwirot University, Bangkok,Thailand. Y1 - 2018 PY - 2018 VL - 19 IS - 12 SP - 3629 EP - 3634 KW - Hepatocellular carcinoma KW - ruptured KW - Thailand DO - 10.31557/APJCP.2018.19.12.3629 N2 - Objective: Hepatocellular carcinoma (HCC) is the fatal cancer worldwide. Spontaneously Rupture remainsimportant complication of HCC. The incidence of spontaneous HCC rupture was high in ASEAN but limited studieswere reported. The aim of this study was to evaluate predictors and overall survival of ruptured HCC in tertiary carecenter in Thailand. Methods: We conducted a retrospective cohort study of HCC patients aged ≥15 years old duringJanuary 2012-January 2016 and followed up through June 2016 at Thammasat University Hospital, Thailand. Allclinical information, laboratory and radiologic findings were collected from reviewing computer data base of medicalrecords. Results: 333 patients had completely retrievable information. Of which, 51patients (15.3%) had spontaneousruptured HCC. Clinical symptoms with abdominal discomfort and anemic symptoms were significantly higher inruptured than non-ruptured HCC groups. (76.47% vs.39.36%: p<0.001, 13.73vs.0.71%, p<0.001). Furthermore, sizeof tumors, presences of metastasis and serum AFP>200 ng/mL were significantly higher in ruptured than non-rupturedHCC groups (10.29cm. vs. 6.47cm. p<0.001, 17.65% vs. 8.16%, p=0.034, 60.78% vs. 36.88%, p=0.001, respectively).In multivariate analysis, age, abdominal discomfort, anemic symptoms, Child-Pugh score>6 were independent riskfactors of HCC rupture (OR=0.96, 95%CI=0.93-0.99, p=0.02; OR=3.47, 95%CI=1.26-9.6, p=0.016; OR=54.51,95%CI=7.09-418.89, p<0.001; OR=2.62, 95%CI=1.09-6.31, p=0.031, respectively). 1-year and 2-year survival ratesof ruptured HCC were 66.9% and 44.6% respectively. Conclusions: Age, abdominal discomfort, anemic symptomsand Child-Pugh score>6 might be predictive factors of spontaneous ruptured HCC. Ruptures of HCC remained a fataldisease with poor survival rate in Thailand. Appropriate treatment in early stage could be effective tool to improve thetreatment outcomes UR - https://journal.waocp.org/article_77415.html L1 - https://journal.waocp.org/article_77415_ee57f2e6297bb6c362cc09c7c3a6145a.pdf ER -