TY - JOUR ID - 77417 TI - Association of IL-10 rs1800871 and rs1800872 Polymorphisms with Breast Cancer Risk: A Systematic Review and Meta-Analysis JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Moghimi, Mansour AU - Ahrar, Hossein AU - Karimi-Zarchi, Mojgan AU - Aghili, Kazem AU - Salari, Marjansadat AU - Zare-Shehneh, Masoud AU - Neamatzadeh, Hossein AD - Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AD - Department of Biology, Ashkezar Branch, Islamic Azad University, Yazd, Iran. AD - Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Y1 - 2018 PY - 2018 VL - 19 IS - 12 SP - 3353 EP - 3359 KW - breast cancer KW - Interleukin-10 KW - Polymorphism KW - Meta-analysis DO - 10.31557/APJCP.2018.19.12.3353 N2 - Background: The rs1800871 and rs1800872 polymorphisms of interleukin 10 (IL-10) gene has been indicated tobe associated with breast cancer (BC) risk, but study results are still debatable. To derive a more precise evaluation, weperformed a comprehensive meta-analysis. Methods: Multiple electronic databases were searched to identify studiesassessing the IL-10 rs1800871 and rs1800872 polymorphisms with BC risk. Results: A total of 21 case-control studieswith 6054 cases and 6355 controls were included in this met-analysis. There was a significant association between thers1800871 polymorphism and BC risk (CT vs. TT: OR= 1.17, 95% CI 1.01-1.35, p=0.02; and CC+CT vs. TT: OR= 1.29,95% CI 1.00-1.66, p=0.04). Moreover, increased BC risks were also associated with the rs1800872 polymorphism (Cvs. A: OR= 1.29, 95% CI 1.04-1.60, p=0.01; CC vs. AA: OR= 1.54, 95% CI 1.03-2.30, p=0.03; CC+CA vs. AA: OR=1.43, 95% CI 1.01-2.01, p=0.03; and CC vs. CA+AA: OR= 1.23, 95% CI 1.01-1.51, p=0.04). A pooling of the studieswas also conducted by ethnicity, but failed to show an association of IL-10 rs1800871 and rs1800872 polymorphismwith BC risk in Asians and Caucasians. Conclusions: Our results are inconsistent with previous meta-analysis suggeststhat IL-10 rs1800871 and rs1800872 polymorphisms might contribute to BC susceptibility in overall population, butnot by ethnicity. UR - https://journal.waocp.org/article_77417.html L1 - https://journal.waocp.org/article_77417_52a43dd5a140e41f1052c6e419b48ddf.pdf ER -