TY - JOUR ID - 82410 TI - Study of Thymidylate Synthase (TS) and Dihydropyrimidine Dehydrogenase (DPD) Expressions on 5-Fluorouracil in Oral Squamous Cell Carcinoma JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Akhter, Khaleda AU - Enamur Rashid, Mohammed AD - Department of Periodontology and Oral Pathology, (Division of Oral Medicine), Pioneer Dental College and Hospital, Dhaka University, Dhaka, Bangladesh. AD - Department of Oral Basic and Clinical Sciences, (Division of Oral Biology), College of Dentistry, Taibah University, Al Medina Al Munawara, Kingdom of Saudi Arabia. Y1 - 2019 PY - 2019 VL - 20 IS - 2 SP - 503 EP - 508 KW - cancer KW - Chemotherapy KW - Dihydropyrimidine Dehydrogenase KW - Prognosis KW - thymidylate synthase DO - 10.31557/APJCP.2019.20.2.503 N2 - Background: The study aims to analyze Thymidylate Synthase (TS) and Dihydropyrimidine Dehydrogenase(DPD) Expressions on 5-Fluorouracil in Oral Squamous Cell Carcinoma (OSCC). Methods: 50 oral squamous cellcarcinoma samples were taken from non-treated cancer patients at Hiroshima University Dental Hospital. The patientswere investigated for TS, that included 36 males and 14 females. Additionally, 31 patients were evaluated for DPDthat included 22 males and 9 females. Results: The samples had also undergone clinical and pathological evaluation,immunohistochemical staining, evaluation of immune-staining, enzymatic expression, and statistical analyses. Meanage of the population was 62.1 years. Conclusion: Over-expression of TS contributes significantly to the resistance of5-FU treatment; while inhibition of intra-tumoral DPD increases the sensitivity level. TS levels are not only predictiveof 5-FU response, but also prognostic in clinical value of non-treated cancer patients. UR - https://journal.waocp.org/article_82410.html L1 - https://journal.waocp.org/article_82410_3759db361bcc5fb5fc610cb5c8588a2b.pdf ER -