TY - JOUR ID - 84299 TI - Factors Associated with the Occurrence of Thyroid Nodules in Severely Obese Patients: A Case-Control Study JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Siqueira, Raquel Andrade de AU - Noll, Matias AU - Rodrigues, Ana Paula dos Santos AU - Silveira, Erika Aparecida AD - Department of Thyroid, Hospital Geral de Goiânia (HGG), Brazil. AD - Instituto Federal Goiano, Brazil. AD - Programa de Pós-Graduacão em Ciências da Saúde, Faculdade de Medicina, Universidade Federal de Goiás (UFG), Brazil. Y1 - 2019 PY - 2019 VL - 20 IS - 3 SP - 693 EP - 697 KW - Thyroid cancer. Cancer. Risk factors KW - HOMA-IR KW - Vitamin D DO - 10.31557/APJCP.2019.20.3.693 N2 - Background: The association of obesity with the occurrence of thyroid nodules and thyroid cancer has beendemonstrated. However, there is limited knowledge on the risk factors of thyroid nodules in in severely obese patients.The aim was to evaluate the occurrence of thyroid nodules in severely obese and nonobese patients and determine thefactors associated considering sociodemographic, lifestyle, and biochemical variables. Methods: This is a case-controlstudy of 134 adults which 67 nonobese, control group, and 67 severely obese (BMI ≥ 35 kg/m2), case group. Allparticipants underwent thyroid ultrasound. Results: The occurrence of thyroid nodules in a control group was 13.4% (n= 9), while in a case group was 29.9%, n = 20), difference statistically significant (p = 0.017). Factors associated withthe occurrence of thyroid nodules in severely obese patients were lower mean age (p = 0.022); higher economic class(p = 0.010); nonconsumption of alcohol (p = 0.017); higher fasting glycemia (p = 0.009), fasting insulin (p = 0.001),homeostatic model assessment of insulin resistance [HOMA-IR] (p = 0.045), and triglyceride (p = 0.009) mean values;and lower vitamin D3 (p = 0.045) and high-density lipoprotein cholesterol (p = 0.041) mean values. Conclusions:Occurrence of thyroid nodules in severely obese patients was higher than nonobese. Lower age at diagnosis, highereconomic level, nonconsumption of alcohol, hyperinsulinemia, higher HOMA-IR scores, and lower vitamin D3 levelswere factors associated with the occurrence of thyroid nodules in severely obese patients. UR - https://journal.waocp.org/article_84299.html L1 - https://journal.waocp.org/article_84299_c4776d069f91155e76c4bcde87a1c7b6.pdf ER -