TY - JOUR ID - 84935 TI - Comparison of Plasma Zinc Levels Among HIV+ and HIV- Subjects Infected with Condyloma Acuminata JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Wiraguna, Anak Agung Gde Putra AU - Andriani, Putu Indah AU - Adiguna, Made Swastika AD - Department of Dermatology-Venereology, Faculty of Medicine, Udayana University-Sanglah General Hospital, Bali, Indonesia. AD - Pre Graduate in Dermatology and Venereology Medicine, Faculty of Medicine, Udayana University-Sanglah General Hospital, Bali, Indonesia. Y1 - 2019 PY - 2019 VL - 20 IS - 3 SP - 943 EP - 949 KW - Condyloma acuminata KW - HPV KW - HIV KW - plasma zinc levels DO - 10.31557/APJCP.2019.20.3.943 N2 - Background: Condyloma acuminata is a type of human papilloma virus (HPV) infection in the anogenital areaand often associated with immunosuppressive conditions, such as human immunodeficiency virus (HIV). Low plasmazinc levels could cause alteration of cellular immunity, leading to reduction of interleukin-2 (IL-2) and interferon-γ(IFN-γ), cytokines required for inhibition of HPV replication. Moreover, low plasma zinc levels could cause disruptionof apoptotic regulation, results in the unimpeded proliferation of epithelial cells infected with HPV. This study aimed tocompare the mean plasma zinc levels in condyloma acuminata patients with HIV and without HIV infection. Methods:This study used a cross-sectional method, involving 27 condyloma acuminata patients without HIV infection and 18patients with HIV infection, who agreed to enroll and signed the informed consent. This study was conducted in thedermatology and venereology outpatient clinic in Sanglah Hospital and Kerti Praja Foundation, Denpasar. Bivariateanalysis of the characteristics, age, sex orientation, location of lesion, clinical form of lesion, type of cases, durationof condyloma acuminata, age of the first sexual contact, comorbidity, treatment history, and mean plasma zinc levelof condyloma acuminata patients with HIV and without HIV infection. The CD4+ cell count and history of ARVtreatment were also obtained form patients with HIV infection. Results: A total of 45 subjects were diagnosed withcondyloma acuminata, consisted of 27 subjects with condyloma acuminata without HIV infection and 18 subjects withHIV infection, showing average age of 32.04 ± 10.414. Mean plasma zinc levels in condyloma acuminata patientswith HIV infection was significantly lower than subjects without HIV infection, and the difference in mean plasmazinc levels was 7.31 μg/dL (95% CI 2.25 - 12.37, p <0.05). Conclusions: The mean plasma zinc levels in condylomaacuminata patients with HIV was significantly lower than those of without HIV infection. UR - https://journal.waocp.org/article_84935.html L1 - https://journal.waocp.org/article_84935_75647a8999dc48e7697bd1905be955fa.pdf ER -