TY - JOUR ID - 85948 TI - Prevalence of HER2 Expression and Its Correlation with Clinicopathological Parameters in Gastric or Gastroesophageal Junction Adenocarcinoma in North-East Indian Population JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Roy, Partha S AU - Nyodu, Tomar AU - Hazarika, Munlima AU - Saikia, B J AU - Bhuyan, C AU - Inamdar, Amit AU - Nyuthe, C W AU - Borthakur, B AU - Sharma, J D AD - Department of Medical Oncology, Dr B Borooah Cancer Institute, Guwahati, Assam, India. AD - Department of Surgical Oncology, Dr B Borooah Cancer Institute, Guwahati, Assam, India. AD - Department of Pathology, Dr B Borooah Cancer Institute, Guwahati, Assam, India. Y1 - 2019 PY - 2019 VL - 20 IS - 4 SP - 1139 EP - 1145 KW - Gastric cancer KW - gastroesophageal adenocarcinoma KW - human epidermal factor receptor KW - immunohistochemistry KW - Overexpression DO - 10.31557/APJCP.2019.20.4.1139 N2 - Objective: Human epidermal growth factor receptor 2 (erbb2/HER2) overexpression, has now been implicatedin advanced gastric and gastroesophageal junction cancers. The study was conducted to determine the rate of HER2positivity in patients with locally advanced or metastatic gastric and gastroesophageal adenocarcinoma in North-EastIndia and to assess the impact of various demographic and clinical parameters on HER2 positivity. Methods: A total of68 patients of age >18 years of gastric and gastroesophageal adenocarcinoma diagnosed on histopathological examinationfrom September 2016 to February 2018 at Dr B Borooah Cancer Institute, Assam were enrolled for the observational(epidemiological) study. All patients were subjected to the HER2 immunohistochemistry test using a FDA-approved,standardized test kit. HER2 expression was correlated with various demographic and clinicopathological parameters.Results: The overall rate of HER2 positivity in the population studied was 56% (n=38). The rate was non-significantlyhigher in male, older age group (>60 years) and Hindu population. Similarly, HER2 positivity rate was higher in patientswith well differentiated histology and was more common in patients with stage II and III diseases, but neither of theassociations is statistically significant. HER2 positivity rate was significantly higher in proximal and in GEJ tumours(56% versus 44%, P=0.002). Conclusion: HER2 overexpression was evident in 56% of the North-East Indian patientswith locally advanced and metastatic gastric and gastroesophageal adenocarcinoma. The overexpression correlatedsignificantly with primary tumour site. Routine testing of gastric and gastroesophageal tumours for HER2 expressionis recommended to provide a therapeutic advantage in Indian patients. UR - https://journal.waocp.org/article_85948.html L1 - https://journal.waocp.org/article_85948_a44b032e164ac33af54c3ce141d73590.pdf ER -