TY - JOUR ID - 88611 TI - Association of Matrix Metalloproteinase1-1607 1G>2G Polymorphism and Lung Cancer Risk: An Update by Meta-Analysis JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Ma, Yue AU - Yang, Xi AU - Xie, Yu-Ping AU - Yi, Cheng AU - Zhao, Fen AU - Huang, Ying AD - Department of Pathophysiology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China. AD - Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China. AD - Department of Oncology, Chengdu First People&#039;s Hospital, Chengdu 610041, Sichuan Province, China. Y1 - 2019 PY - 2019 VL - 20 IS - 6 SP - 1841 EP - 1847 KW - matrix metalloproteinase1 (MMP1) KW - Lung cancer KW - Polymorphism KW - Meta-analysis DO - 10.31557/APJCP.2019.20.6.1841 N2 - Objective: The association between matrix metalloproteinase1 (MMP1)-1607 1G>2G polymorphism and lung cancerrisk is still inconclusive and inconsistent. We conducted a meta-analysis to estimate the potential relationship betweenMMP1-1607 1G>2G polymorphism and lung cancer risk. Methods: The comprehensive searches of the PubMed, Webof Science, Medline, CBM, CNKI, Weipu, and Wanfang databases, published up to Nov 10, 2018. Statistical analyseswere performed with Review Manager 5.3 software. Results: A total of 14 relevant studies containing 6068 cases and5860 controls were included in the study. The results indicated that MMP1-1607 1G>2G polymorphism was significantlyassociated with increased lung cancer risk under four models: 2G vs. 1G model (pooled OR = 1.19, 95% CI = 1.05-1.34,P < 0.0001); 2G/2G vs. 1G/1G (pooled OR = 1.34, 95% CI = 1.09-1.64, P = 0.003); 2G/2G vs. 1G/1G+1G/2G (pooledOR = 1.26, 95% CI = 1.06-1.49, P < 0.0001); 2G/2G+1G/2G vs. 1G/1G (pooled OR = 1.21, 95% CI = 1.05-1.40, P= 0.01). Subgroup analyses showed that there was a higher increase in smoking status under three models: 2G/2Gvs. 1G/1G (pooled OR = 2.07, 95% CI = 1.14-3.77, P = 0.02); 2G/2G vs. 1G/1G+1G/2G (pooled OR = 1.71, 95% CI= 1.17-2.52, P = 0.006); 2G/2G+1G/2G vs. 1G/1G (pooled OR = 2.03, 95% CI = 1.14-3.62, P = 0.02). In addition,subgroup analyses by ethnicity further identified the significant association in Asians. Non-smoking population andethnicity among Caucasian had no relationship with lung cancer susceptibility in four models. Conclusion: Our studysuggested that MMP1-1607 1G>2G polymorphism was a risk factor for developing lung cancer risk. UR - https://journal.waocp.org/article_88611.html L1 - https://journal.waocp.org/article_88611_19f6acf39f11df2f5f9daa68a76e1a0c.pdf ER -