TY - JOUR ID - 88621 TI - Expression of miR-9 and miR-200c, ZEB1, ZEB2 and E-cadherin in Non-Small Cell Lung Cancers in Iran JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Nourmohammadi, Bahareh AU - Tafsiri, Elham AU - Rahimi, Amirabbas AU - Nourmohammadi, Zahra AU - Daneshvar Kakhaki, Abolghasem AU - Cho, William AU - Karimipoor, Morteza AD - Department of Molecular Medicine, Biotechnology Research center, Pasteur Institute of Iran, Tehran, Iran. AD - Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. AD - Tracheal Diseases Research Center (TDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong, China. Y1 - 2019 PY - 2019 VL - 20 IS - 6 SP - 1633 EP - 1639 KW - MicroRNAs KW - miR-9 KW - miR-200c KW - non-small cell lung cancer DO - 10.31557/APJCP.2019.20.6.1633 N2 - MicroRNAs (miRNAs) exert a critical influence on physiological and pathological processes through posttranscriptionalmodification of their mRNA targets. They play important roles in tumorigenesis and are considered tobe potential diagnostic and prognostic biomarkers with various cancers. MiR-200c and miR-9 are regulatory elementsthat can have dual impacts as oncogenes and/or tumor suppressor genes. MiR-200c regulates two transcription factors,ZEB1 and ZEB2, while miR-9 is a regulatory factor for the E-cadherin protein which has a critical function in cell-celljunctions and is inhibited by two transcription factors ZEB1 and ZEB2. In this study, expression levels of miR-200cand miR-9, ZEB-1, ZEB-2 and E-cadherin were assessed in 30 non-small cell lung cancers (NSCLCs) by real-timeqPCR. MiR-9 was down-regulated significantly in tumor tissues compared to normal adjacent tissues, while there wasno significant change in expression level of miR-200c. On the other hand, ZEB1 demonstrated significant increaseand ZEB2a decrease at the mRNA level. These results indicate roles for miR-9 and ZEB1 in genesis of lung cancer,although clinico-pathological associations were not evident. Further studies are necessary to assess implications fortreatment of lung cancer. UR - https://journal.waocp.org/article_88621.html L1 - https://journal.waocp.org/article_88621_7bd8f28cc4bd920dec14e39407ddb141.pdf ER -