TY - JOUR ID - 88666 TI - Outcome of Combined Neoadjuvant Chemotherapy and Vitamin A in Advanced Cervical Carcinoma: A Randomized Double-Blind Clinical Trial JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Sanusi, Rizal Sanif AD - Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, General Hospital of Dr.Mohammad Hoessin, University of Sriwijaya, Palembang, Sumatra, Indonesia. Y1 - 2019 PY - 2019 VL - 20 IS - 7 SP - 2213 EP - 2218 KW - Cervical cancer KW - NAC KW - Neoadjuvant chemotherapy KW - nutrition KW - vitamin A DO - 10.31557/APJCP.2019.20.7.2213 N2 - Background: The latest World Health Organization (WHO) inquiry on the epidemiology of cervical cancers indicatethere are approximately 528,000 new cases per year, ranking fourth after breast, colorectal and lung cancer. The validityof neoadjuvant chemotherapy (NAC) alone in advanced cervical cancer is still being debated. NAC induces tumorshrinkage prior to pursuing surgery. NAC also has the benefit of sterilizing the lymph nodes and parametria, therebylowering the need for adjuvant therapy after surgery. This research aims to determine the impact on the treatment ofadvanced cervical carcinoma with NAC, with the additional provision of Vitamin A during treatment to assess thefactors that could affect the outcome of clinical treatment. Methodology: The research methodology and design ofthis study is a randomized double-blind clinical trial to compare the effects of treatment with NAC and treatment withNAC + Vitamin A, in advanced cervical carcinoma. Both study groups received treatments consisting of a regime ofcisplatin and paclitaxel. The study was conducted at the General Hospital of Dr. Mohammad Hoesin. The total numberof patients recruited for the trial was 30 with 15 patients per treatment arm. One group received NAC consisting ofcisplatin and paclitaxel and the remaining 15 patients received NAC + Vitamin A. Results: The addition of VitaminA was found to be much better in influencing the clinical response in the treatment of advanced cervical carcinoma,although this was not statistically significant. However, a larger sample size with the reported proportion of higherpositive outcome for NAC + Vitamin A may be statistically significant. Conclusion: Based on the results, Vitamin Asupplementation in the treatment of advanced cervical carcinoma with neoadjuvant chemotherapy may play a crucialrole in the treatment of cervical carcinoma. UR - https://journal.waocp.org/article_88666.html L1 - https://journal.waocp.org/article_88666_85145816adbed6c1e7b7e14b975b609b.pdf ER -