TY - JOUR ID - 88676 TI - Luminal B is the Most Common Intrinsic Molecular Subtypes of Invasive Ductal Breast Carcinoma Patients in East Kalimantan, Indonesia JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Paramita, Swandari AU - Raharjo, Eko Nugroho AU - Niasari, Maria AU - Azizah, Fieska AU - Hanifah, Nur Ahlina AD - Department of Community Medicine, Faculty of Medicine, Mulawarman University, Samarinda, East Kalimantan, Indonesia. AD - Department of Pathological Anatomy, Abdul Wahab Sjahranie General County Hospital, Samarinda, East Kalimantan, Indonesia. AD - Medical Doctor Program, Faculty of Medicine, Mulawarman University, Samarinda, East Kalimantan, Indonesia. Y1 - 2019 PY - 2019 VL - 20 IS - 8 SP - 2247 EP - 2252 KW - luminal B KW - intrinsic molecular subtypes KW - Breast carcinoma DO - 10.31557/APJCP.2019.20.8.2247 N2 - Objective: Breast carcinoma has no longer been considered as a single and standalone disease. Its subtypes havebeen known to vary in terms of risk factors, natural histories, and responses to therapies. In particular, intrinsic molecularsubtypes based on St. Gallen International Expert Consensus 2013 have classified breast carcinoma into luminal A,luminal B, HER2+, and triple-negative, depending on the expression of ER, PgR, HER2, and Ki-67. Research onintrinsic molecular subtypes of breast carcinoma in Indonesia, however, are rarely conducted, which then triggersthe intention to conduct this study. Methods: In this work, a retrospective study was conducted on 92 formalin-fixedparaffin-embedded samples of invasive ductal breast carcinoma patients. These samples were from patients at AbdulWahab Sjahranie County General Hospital Samarinda, East Kalimantan, Indonesia, in 2016. Next, immunohistochemicalstaining using anti-ER, PgR, HER2, and Ki-67 antibodies was applied to classify intrinsic molecular subtypes. Then, anassociation between clinical and immunohistochemical factors with intrinsic molecular subtypes of breast carcinomawere analyzed using Chi-square test. Results: Looking at results of the retrospective study, luminal B was discovered asthe most common intrinsic molecular subtypes of breast carcinoma (42.39%) in East Kalimantan, Indonesia. The nextranks of breast carcinoma subtypes in the region included HER2+ (39.13%), triple-negative (10.87%), and luminal A(7.61%). In fact, there was a significant association between age (p = 0.019) with intrinsic molecular subtypes of breastcarcinoma. Conclusion: The study found luminal B as the most common intrinsic molecular subtypes of Indonesianbreast carcinoma in the region under investigation. In the future, the higher positivity rate of luminal B in breastcarcinoma patients compared to prior studies would require further investigations. UR - https://journal.waocp.org/article_88676.html L1 - https://journal.waocp.org/article_88676_c2d42db0c4c9ddb9e8671caaea76bb1d.pdf ER -