TY - JOUR ID - 88723 TI - Cytotoxicity Profiling of Annona Squamosa in Cancer Cell Lines JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Vikas, Biba AU - Anil, Sukumaran AU - Remani, P AD - Regional Cancer Centre, Thiruvananthapuram, India. AD - Department of Dentistry, Hamad Medical Corporation, Doha, Qatar. Y1 - 2019 PY - 2019 VL - 20 IS - 9 SP - 2831 EP - 2840 KW - Anticancer KW - Cytotoxicity KW - Annona squamosa DO - 10.31557/APJCP.2019.20.9.2831 N2 - Objective: In the study our aim was to evaluate the cytotoxic activity of different solvent extracts of Annona squamosa seeds. Methods and materials: The four extracts used were petroleum ether, chloroform, ethyl acetate and methanol were tested using cytotoxicity assays. Results: Among the four extracts tested petroleum ether showed maximum cytotoxicity against a panel of cancer cell lines such as nasopharyngeal cancer (KB) cells, lung cancer (A-549) cells, breast cancer (MCF- 7) cells, leukemic (K-562) cells and inhibited the growth of murine cancer cells such as Dalton’s lymphoma ascites (DLA) and Ehrlich ascites carcinoma (EAC). Conclusion: Petroleum ether extract of Annona squamosa seeds showed cytotoxicity towards a panel of cancer cells meanwhile non-significant cytotoxicity towards normal cells. UR - https://journal.waocp.org/article_88723.html L1 - https://journal.waocp.org/article_88723_9b8fff9d568a72f1a6f5f27db45b4e5d.pdf ER -