TY - JOUR ID - 88751 TI - The Effect of Combination of Steroid and L-Asparaginase on Hyperglycemia in Children with Acute Lymphoblastic Leukemia (ALL) JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Aisyi, Mururul AU - Andriastuti, Murti AU - Kurniati, Nia AD - Department of Pediatric Hematology Oncology, Indonesian National Cancer Center “Dharmais” Cancer Hospital, Jakarta, Indonesia. AD - Department of Child Health, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Y1 - 2019 PY - 2019 VL - 20 IS - 9 SP - 2619 EP - 2624 KW - Hyperglycemia KW - ALL induction phase KW - steroid KW - L-asparaginase DO - 10.31557/APJCP.2019.20.9.2619 N2 - Background: Hyperglycaemia is a common side effect of steroid and L-asparaginase combinations, occurring mostoften during acute lymphoblastic leukemia (ALL) induction phase. To date in Indonesia, it has not been obtained dataon the incidence of hyperglycemia in children with ALL in the induction phase and how the role of combinations ofL-asparaginase and different type of steroid used. The purpose of this study is to determine the incidence of hyperglycemiain children ALL induction phase, knowing the difference between prednisone and dexamethasone (in combination withL-asparaginase) in causing hyperglycemia in children with ALL and determine the relationship of other factors relatedto hyperglycaemia. Methods: This was a prospective analytic study with a pre- and post-test design, conducted inthree hospitals (Cipto Mangunkusumo Hospital, Dharmais Cancer Hospital, and Gatot Soebroto Hospital). Patient’sblood glucose levels were checked at the 3rd (pretest), 4th, 5th and 6th week of protocol (post-test). Result: Of the57 patients, 5.26% had hyperglycemia. The patients’ age ranged from 1.4 years old to 15.8 years old (6.7 years old).There was no relationship between age, CNS infiltration, leukocytosis, Down syndrome, nutritional status, familyhistory of diabetes, infections and ALL stratification with hyperglycemia (p>0.05). Dexamethasone has more chanceof obtaining higher mean rate of change in blood glucose levels compared to prednisone. (p < 0.05; RR 10.68; CI 95%1.52-74.73). Conclusion: The incidence of hyperglycemia in this study is 5.26%. Dexamethasone, in combinationwith L-asparaginase, despite having no difference in causing hyperglycemia, has an increased risk of changing bloodglucose levels compared to prednisone. UR - https://journal.waocp.org/article_88751.html L1 - https://journal.waocp.org/article_88751_48145c0d3b21013bd6c2d93094ab9722.pdf ER -