TY - JOUR ID - 88834 TI - Neonatal Weight and Prenatal Exposure to Polychlorinated Biphenyls: A Meta-Analysis JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Zou, Hongling AU - Lin, Yinxia AU - Yang, Liu AU - Ou, Chaoyan AU - Geng, Fang AU - Wang, Yao AU - Chen, Wanrong AU - Niu, Yali AU - Liang, Rimei AU - Su, Qianzi AU - Sun, Yi AD - Department of Oncology, Second Affiliated Hospital of Guilin Medical College, Guilin, China. AD - Department of Toxicology, Guilin Medical University School of Public Health, Guilin, China. AD - Department of Clinical Laboratory, Tangshan Maternity and Children’s Health Care Hospital, Tangshan, Hebei, China. Y1 - 2019 PY - 2019 VL - 20 IS - 11 SP - 3251 EP - 3258 KW - Polychlorinated biphenyls KW - Birth weight KW - Meta-analysis DO - 10.31557/APJCP.2019.20.11.3251 N2 - Background: This research studied the relationship between maternal exposure to polychlorinated biphenyls and neonatal birth weight through systematic review and meta-analysis of existing literature. Methods:We searched for all the studies published in MEDLINE / PUBMEDN / EMBASE (Medical Abstract Database) by June 2018, and seven studies had been selected. Results:The results showed that there was significant correlation between birth weight reduction and PCBS exposure throughout pregnancy (β=-0.586g, 95%CI:-0.629,-0.543). There was a negative correlation between birth weight and PCBs exposure and umbilical cord serum (β=-0.833g) and maternal serum (β= -0.504g).Subgroup analyses showed significantly different effects of PCBs exposure on birth weight in different regions, stages of pregnancy and study designs. It was thought the heterogeneity was mainly caused by geographical regions, stages of pregnancy, and the assessment methods. Conclusion: The meta analysis revealed a negative correlation between PCBs exposure and birth weight but there was significant difference in the correlation between birth weight loss. UR - https://journal.waocp.org/article_88834.html L1 - https://journal.waocp.org/article_88834_d23e8ca4ac8f22c12c1d341c25dde82f.pdf ER -