TY - JOUR ID - 88924 TI - Association between SNPs and Loss of Methylation Site on the CpG island of the Promoter Region of the Smoothened Gene, Potential Molecular Markers for Susceptibility to the Development of Basal Cell Carcinoma in the Brazilian Population JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Souza, Augusto Monteiro de AU - Lopes, Otávio Sérgio AU - Liberato, Andressa de Lima AU - Oliveira, Paulo Junior Ribeiro de AU - Herrero, Sylvia Satomi Takeno AU - Nascimento, Agnaldo Luiz do AU - Longui, Carlos Alberto AU - Carvalho Filho, Ivan Rodrigues de AU - Soares, Leonardo Ferreira AU - Silva, Renally Barbosa da AU - Burbano, Rommel Rodriguez AU - Delatorre, Plínio AU - Lima, Eleonidas Moura AD - Laboratory of Structural Molecular Biology and Oncogenetics - LBMEO, Federal University of Paraiba, João Pessoa - PB, Brazil. AD - Department of Dermatology, Dermatological Clinic Santa Catarina, João Pessoa - PB - Brazil. AD - Postgraduate Program in Health Sciences; Santa Casa School of Medical Sciences of São Paulo; Sao Paulo – SP, Brazil. AD - Depathology of Pathology, Laboratory of Medical Analysis - UNILAB, João Pessoa - PB, Brazil. AD - 6Pharmacy Department; State University of Paraíba; Campina Grande – PB, Brazil. AD - Postgraduate Program in Natural Sciences and Biotechnology, Federal University of Campina Grande - UFCG, Campus de Cuité – PB, Brazil. AD - Institute of Biological Sciences; Federal University of Pará; Belém - PA - Brazil Brazil. Y1 - 2020 PY - 2020 VL - 21 IS - 1 SP - 25 EP - 29 KW - Basal cell carcinoma KW - CpG-SNPs KW - via Hedgehog KW - molecular markers e DSAPS DO - 10.31557/APJCP.2020.21.1.25 N2 - Objective: Perform genotyping of SNPs in the promoter region of the SMO gene in BCC samples from patients from northeastern Brazil, and to determine if there is an association of these SNPs of the gene in question with the susceptibility to the development of the BCC. Methods: 100 samples of paraffined tissue from patients with histopathological diagnosis of BCC and 100 control samples were analyzed for each polymorphism by a newly developed genotyping method, the Dideoxy Single Allele Specific – PCR. The software Bioestat - version 5.3 and Haploview 4.2 were used for the statistical analysis. For all tests a P-value   UR - https://journal.waocp.org/article_88924.html L1 - https://journal.waocp.org/article_88924_4fdd19c21cc0d3fc660d3a24fafe500f.pdf ER -