TY - JOUR ID - 88962 TI - Can the Irisin be a Biomarker for Prostate Cancer? A Case Control Study JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Aslan, Rahmi AU - Alp, Hamit Hakan AU - Eryılmaz, Recep AU - Huyut, Zubeyir AU - Sevim, Mehmet AU - Araz, Şeyhmuz AU - Ertas, Kasim AU - Taken, Kerem AD - Department of Urology, Faculty of Medicine, Van Yuzuncu Yıl University, 65080-Van, Turkey. AD - Department of Medical Biochemistry, Faculty of Medicine, Van Yuzuncu Yıl University, 65080-Van, Turkey. Y1 - 2020 PY - 2020 VL - 21 IS - 2 SP - 505 EP - 509 KW - adipokine KW - Biomarker KW - irisin KW - prostate cancer (PCa) DO - 10.31557/APJCP.2020.21.2.505 N2 - Aim: There is much evidence of an association between cancer and irisin that is an adipokine. This study researched on the relationship between prostate cancer (PCa) and irisin levels, and whether irisin can be used as a biomarker in the diagnosis of PCa. Materials and Methods: For the study groups, 50 primary PCa patients and 30 healthy male subjects were included in the PCa and healthy control groups, respectively. All volunteers in the healthy control group were screened for prostate cancer and other malignancies and chronic diseases. Volunteers who were determine to be completely healthy were included for healthy control group. In the serum samples of the subjects were measured free PSA, total PSA and irisin levels. Irisin levels were compared separately in terms of the Gleason scores and T stage. In addition to intergroup comparisons, the ROC curve for the irisin was plotted and power analysis was performed. Results: Free and total PSA levels in the PCa group were significantly higher compared to the healthy control group (p<0.05). In addition, irisin levels in the PCa group were significantly lower  than in the healthy control group (p<0.05). There was no significant difference between irisin levels in the groups classified in terms of Gleason scores (p>0.05).  When the cut-off value was taken as 8.1, the sensitivity and specificity of irisin for PCa were as 80.5% and 90%, respectively. Conclusion: The results of this study indicate that the levels of irisin in the PCa group are considerably reduced and irisin may be used as a biomarker as well as free and total PSA. UR - https://journal.waocp.org/article_88962.html L1 - https://journal.waocp.org/article_88962_d34561da5270e31ce1fa48f2cb78a2e4.pdf ER -